In H.G. Well's novel The Island of Dr. Moreau He tells the tale of a man making human/animal hybrids. Makes for a good story.
"Dr. Moreau and his assistant perished at the hands of their experiments. Prendick escaped and returned to England. And, as the novel concludes, Prendick, in England, said that, as he looked at the people around him, he could not help feeling that he was still amongst the beast-people of Dr. Moreau's island; and, that they might, at any point, turn on him, the way that the creatures of the island had."